The 1942 Ecuador earthquake or the Guayaquil earthquake occurred on 13 May at 21:13 ECT with a moment magnitude (Mw ) of 7.8–7.9. The earthquake had an epicenter near the coast of Manabí Province, Ecuador. It killed more than 300 people and the total cost of damage was about US$2.5 million. At Guayaquil, 250 km (160 mi) from the epicenter, many reinforced concrete structures in the city were destroyed and high-rise buildings collapsed. At least 100 fatalities were recorded in the city.
The earthquake was caused by movement on a section of the Ecuador–Colombia subduction zone, a seismically active area where the Nazca plate subducts beneath the overriding South American plate.