Mission San Luis Rey de Francia (Spanish: Misión San Luis Rey de Francia) is a former Spanish mission in San Luis Rey, a neighborhood in Oceanside, California. This Mission lent its name to the Luiseño tribe of Mission Indians.
At its prime, Mission San Luis Rey's structures and services compound covered almost 950,400 acres (384,600 ha), making it the largest of the Californian missions, along with its surrounding agricultural land. Multiple outposts were built in support of Mission San Luis Rey and placed under its supervision, including the San Antonio de Pala Asistencia in 1816 and the Las Flores Estancia in 1823.