On This Day

Uprising against Piero de' Medici in Florence

Florence (Italian: Firenze) is the capital and most populous city of the Italian region of Tuscany, with 362,353 inhabitants as of 2025.

Florence (Italian: Firenze) is the capital and most populous city of the Italian region of Tuscany, with 362,353 inhabitants as of 2025. It is also the capital of the eponymous metropolitan province, which counts 989,460 inhabitants. Florence was a centre of medieval European trade and finance and one of the wealthiest cities of that era. It is considered by many academics to have been the birthplace of the Renaissance, becoming a major artistic, cultural, commercial, political, economic and financial center. During this time, Florence rose to a position of enormous influence in Italy, Europe, and beyond. Its turbulent political history includes periods of rule by the powerful Medici family and numerous religious and republican revolutions.

Historical Significance

Florence (Italian: Firenze) is the capital and most populous city of the Italian region of Tuscany, with 362,353 inhabitants as of 2025.

Events Before

  1. Christopher Columbus returns to Spain after his first voyage to the New World

    Christopher Columbus returns to Spain after his first voyage to the New World

  2. Spanish Pope Alexander VI decrees in the papal bull "Inter caetera" that all lands west of a line 100 leagues west of an

    Spanish Pope Alexander VI decrees in the papal bull "Inter caetera" that all lands west of a line 100 leagues west of any of the islands of the Azores or the Cape Verde Islands belong to Castile, ultimately dividing the Americas between Spain and Portugal

  3. Christopher Columbus embarks on his second expedition to the New World, setting sail with a fleet of 17 ships

    Christopher Columbus embarks on his second expedition to the New World, setting sail with a fleet of 17 ships

  4. Christopher Columbus returns to the colony of La Navidad, finding it destroyed by the first Native American uprising aga

    Christopher Columbus returns to the colony of La Navidad, finding it destroyed by the first Native American uprising against Spanish rule. Taíno Cacique Caonabo led his people to attack the settlement after the brutal treatment they received from the garrison who disobeyed Columbus's orders.

  5. Last day for all Jews to leave Sicily

    Jews, or the Jewish people, are an ethnoreligious group and nation, originating from the Israelites of ancient Israel and Judah. They traditionally adhere to Judaism.

Events After

  1. First written record of Scotch whisky appears in the Exchequer Rolls of Scotland, Friar John Cor is listed as the distil

    First written record of Scotch whisky appears in the Exchequer Rolls of Scotland, Friar John Cor is listed as the distiller

  2. King Ferdinand II returns to Naples

    King Ferdinand II returns to Naples

  3. French viceroy of Naples Montpensier surrenders

    French viceroy of Naples Montpensier surrenders

  4. Leonardo da Vinci unsuccessfully tests a flying machine

    Leonardo da Vinci unsuccessfully tests a flying machine

  5. Joanna of Aragon marries Philip of Flanders, future King Philip I of Castile

    Joanna of Aragon marries Philip of Flanders, future King Philip I of Castile

More from the 1490s

Frequently Asked Questions

What happened on November 8, 1494?
Florence (Italian: Firenze) is the capital and most populous city of the Italian region of Tuscany, with 362,353 inhabitants as of 2025. It is also the capital of the eponymous metropolitan province, which counts 989,460 inhabitants. Florence was a centre of medieval European trade and finance and one of the wealthiest cities of that era.
Why is Uprising against Piero de' Medici in Florence significant?
Florence (Italian: Firenze) is the capital and most populous city of the Italian region of Tuscany, with 362,353 inhabitants as of 2025.

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