The 1880 Republican National Convention was held from June 2 to June 8, 1880, at the Interstate Exposition Building in Chicago, Illinois, United States. Delegates nominated James A. Garfield of Ohio and Chester A. Arthur of New York as the official Republican Party candidates for president and vice president in the 1880 presidential election.
Of the 14 men in contention for the Republican nomination, the three strongest leading up to the convention were Ulysses S. Grant, James G. Blaine, and John Sherman. Grant had served two terms as president from 1869 to 1877, and was seeking an unprecedented third term in office. He was backed by the Stalwart faction of the Republican Party, which supported political machines and patronage.