The 2021 Major League Baseball season began on April 1, while the regular season ended on October 3. The postseason began on October 5. The World Series then began on October 26 and ended on November 2 with the Atlanta Braves defeating the Houston Astros in six games to win their second title since moving to Atlanta.
For the second consecutive year, cross-border travel restrictions due to the COVID-19 pandemic forced the Toronto Blue Jays to open their home schedule in the United States, with tenures in Dunedin, Florida, and Buffalo, New York.