First recorded appendectomy performed by Claudius Amyand at St George's Hospital in London

Claudius Amyand (1680 – 6 July 1740) was a French surgeon who performed the first recorded successful appendectomy.

Amyand was born around 1680, the son of Isaac Amyand and Anne Hottot in Mornac, Saintonge, France. As Huguenots, the Amyands fled to England following the revocation of the Edict of Nantes in 1685 and settled in London.

Claudius was naturalised at Westminster on 9 September 1698. He became a surgeon, served with the army during the War of the Spanish Succession, and was appointed Serjeant Surgeon to George I in 1715. He would continue in this post under George II retaining it for the rest of his life. He became first the Warden and later the Master of the Company of Barber-Surgeons.