The 2021 Cleveland Indians season was the 121st season for the franchise. It was the ninth season under the leadership of manager Terry Francona and sixth under general manager Mike Chernoff. The Indians played their home games at Progressive Field in Cleveland, Ohio.
This was the team's final season under the name Indians. Following the season, the team became known as the Cleveland Guardians after decades of controversy surrounding the "Indians" name.
The Indians made MLB history by becoming the first team to be no-hit three times in a single season. Those three no-hitters came off of Carlos Rodón of the Chicago White Sox on April 14, Wade Miley of the Cincinnati Reds on May 7, and Corbin Burnes and Josh Hader of the Milwaukee Brewers on September 11.