The 54th Scripps National Spelling Bee was held in Washington, D.C. at the Capital Hilton on June 3–4, 1981, sponsored by the E.W. Scripps Company.
The winner was 13-year-old Paige Pipkin of El Paso, Texas, who had placed second in the prior year's bee. 12-year-old Jason Johnson Jr. of St. Joseph, Michigan placed second, missing "Philippic". Pipkin spelled that word correctly followed by "sarcophagus" for the win. Pipkin had earlier missed "vitrine" but Johnson also missed it. Third-place went to 13 year old Danielle Marie Spinelli of Staunton, Virginia, who missed "polyonymous".
There were 120 spellers this year, and a total of 571 words were used. 46 spellers made it to the second day. Round 4 on day one was especially harsh on the contestants, knocking out 44 spellers on 90 words.