The 2006 Daytona 500 was the first stock car race of the 2006 NASCAR Nextel Cup Series. The 48th Daytona 500 was held on February 19, 2006, at Daytona International Speedway in Daytona Beach, Florida, before 200,000 spectators. Hendrick Motorsports' Jimmie Johnson, won the 203-lap race after starting ninth. Chip Ganassi Racing's Casey Mears and Penske Racing South's Ryan Newman finished second and third, respectively.
Jeff Burton claimed his third career pole position with the quickest qualifying lap, and led the first 18 laps until the first round of pit stops. Tony Stewart led the next 20 laps from the 28th lap. Matt Kenseth led from laps 58 to 80 until Dale Earnhardt Jr. took it on the 86th. Earnhardt led seven times for a total of 32 laps, more than any other driver.