Samuel Cole (1597–1666/67) was an early settler of Boston in the Massachusetts Bay Colony, arriving with the Winthrop Fleet in 1630. He was an innkeeper and confectioner, and in 1634 established the first house of entertainment in the colony, called Cole's Inn and referenced by Henry Wadsworth Longfellow in his play John Endicott as the Three Mariners.
Born by 1597, Cole and his family arrived in New England with John Winthrop in 1630, and established themselves on the Shawmut Peninsula, which soon became the town of Boston. He and his wife Ann were among the earliest members of the Boston church, having joined in the autumn of 1630.